abstract：:The work was aimed at developing an in vitro method able to provide rapid and reliable evaluation of drug absorption through buccal mucosa. Absorption simulator apparatus endowed with an artificial membrane was purposely developed by experimental design. The apparent permeation coefficient (Papp) through excised porci...

journal_title：International journal of pharmaceutics

authors： Mura P,Orlandini S,Cirri M,Maestrelli F,Mennini N,Casella G,Furlanetto S

更新日期：2018-08-25 00:00:00

abstract：:Since the discovery of amylin its use has been discouraged by the inadequacy of the protocol involving multiple injections in addition to insulin. We aimed here to develop a combined fixed-dose formulation of pramlintide with fast-acting insulin. We have investigated the compatibility of regular and fast-acting insuli...

journal_title：International journal of pharmaceutics

authors： da Silva DC,Lima LMTR

更新日期：2018-08-25 00:00:00

abstract：:The aim of this study was to develop a self-emulsifying drug delivery system (SEDDS) containing the fluoroquinolone antibiotic ciprofloxacin (CIP) exhibiting highly mucus permeating properties and antimicrobial activity in in vitro models. Various SEDDS formulations were developed and evaluated regarding droplet size,...

journal_title：International journal of pharmaceutics

authors： Zaichik S,Steinbring C,Menzel C,Knabl L,Orth-Höller D,Ellemunter H,Niedermayr K,Bernkop-Schnürch A

更新日期：2018-08-25 00:00:00

abstract：:Resistance to antiepileptic drugs (AEDs) is a major clinical problem. The overexpression of P-glycoprotein (Pgp), one of the main transporters limiting the entry of xenobiotics into the brain, is among the factors contributing to the AED resistance. Presently, there is no consensus on the interaction of carbamazepine ...

journal_title：International journal of pharmaceutics

authors： Zybina A,Anshakova A,Malinovskaya J,Melnikov P,Baklaushev V,Chekhonin V,Maksimenko O,Titov S,Balabanyan V,Kreuter J,Gelperina S,Abbasova K

更新日期：2018-08-25 00:00:00

abstract：:Oral administration of proteins and peptides still is a challenging task to overcome due to low permeability through absorptive epithelia, degradation and metabolism that lead to poor bioavailability. Attempting to overcome such limitations, an antihypertensive peptide derived from whey protein, with KGYGGVSLPEW seque...

journal_title：International journal of pharmaceutics

authors： Castro PM,Baptista P,Madureira AR,Sarmento B,Pintado ME

更新日期：2018-08-25 00:00:00

abstract：:Thermogels, used as multi-functional drug-loading materials, have properties that mainly rely on their gelator structure. Although a large variety of organogel systems are used as drug delivery carriers, relatively few have been investigated in terms of their structure-property correlations based on amino acid derivat...

journal_title：International journal of pharmaceutics

authors： Hu B,Sun W,Li H,Sui H,Li S

更新日期：2018-08-25 00:00:00

abstract：:Platelet-rich plasma (PRP) is used in therapy for bone tissue repair because an abundance of osteogenesis-related growth factors can be released from the concentrated platelets. However, its clinical use is limited because growth factors, temporally released from PRP, are degraded rapidly. This study aimed to incorpor...

journal_title：International journal of pharmaceutics

authors： Cheng G,Ma X,Li J,Cheng Y,Cao Y,Wang Z,Shi X,Du Y,Deng H,Li Z

更新日期：2018-08-25 00:00:00

abstract：:Biomaterials for applications in the urinary tract are challenged with both biofilm formation and encrustation, two highly interconnected processes. While great effort has been achieved developing promising materials there is only a limited choice of sophisticated in vitro models that are available to analyse the perf...

journal_title：International journal of pharmaceutics

authors： Frant M,Dayyoub E,Bakowsky U,Liefeith K

更新日期：2018-07-30 00:00:00

abstract：:N-Acetyl-l-cysteine (NAC) commonly used as an antidote in acetaminophen poisoning has shown promise in the treatment of neurological disorders such as cerebral palsy (CP). However, NAC suffers from drawbacks such as poor oral bioavailability and suboptimal blood-brain-barrier (BBB) permeability limiting its clinical s...

journal_title：International journal of pharmaceutics

authors： Yellepeddi VK,Mohammadpour R,Kambhampati SP,Sayre C,Mishra MK,Kannan RM,Ghandehari H

更新日期：2018-07-10 00:00:00

abstract：:The poly(cystaminebis(acrylamide)-diaminohexane) (poly(CBA-DAH)) was designed previously as a bio-reducible efficient gene delivery carrier. However, the high weight ratio required to form the polyplexes between poly(CBA-DAH) with pDNA is still a problem that needs to be addressed. To solve this problem and increase t...

journal_title：International journal of pharmaceutics

authors： Nam JP,Kim S,Kim SW

更新日期：2018-07-10 00:00:00

abstract：:Polysaccharides-based delivery systems and interpolyelectrolyte complexes (IPECs) are interesting alternatives to control the release of drugs, thereby improving therapies. Benznidazole (BZ) is the selected drug for Chagas disease pharmacotherapy. However, its side effects limit its efficacy and safety. We developed n...

journal_title：International journal of pharmaceutics

authors： García MC,Manzo RH,Jimenez-Kairuz A

更新日期：2018-07-10 00:00:00

abstract：:The objective of this study was to investigate the in vitro cytotoxicity and in vivo anticancer efficacy of redox-responsive microbeads containing thiolated pectin-doxorubicin (DOX) conjugate. Oral microbeads were coated with an enteric polymer to protect the drug from release in the upper gastrointestinal (GI) tract ...

journal_title：International journal of pharmaceutics

authors： Cheewatanakornkool K,Niratisai S,Dass CR,Sriamornsak P

更新日期：2018-07-10 00:00:00

abstract：:Dissolution testing for inhalers were previously conducted either on unfractionated drug-carrier powders or drug of specific aerodynamic particle size. In this study, the collection of the full fine particle fraction (FPF) was attempted on a single stage. Capsules containing 30 mg of 2% salbutamol sulfate (SS) was tes...

journal_title：International journal of pharmaceutics

authors： Tay JYS,Liew CV,Heng PWS

更新日期：2018-07-10 00:00:00

abstract：:The high incidence of degenerative tears and prevalence of retears (20-95%) after surgical repair makes rotator cuff injuries a significant health problem. This high retear rate is attributed to the failure of the repaired tissue to regenerate the native tendon-to-bone insertion (enthesis). Biological augmentation of ...

journal_title：International journal of pharmaceutics

authors： Prabhath A,Vernekar VN,Sanchez E,Laurencin CT

更新日期：2018-06-15 00:00:00

abstract：:Insulin replacement therapy is integral to the management of type 1 diabetes, which is characterised by absolute insulin deficiency. Optimal glycaemic control, as assessed by glycated haemoglobin, and avoidance of hyper- and hypoglycaemic excursions have been shown to prevent diabetes-related complications. Insulin pu...

journal_title：International journal of pharmaceutics

authors： Bally L,Thabit H,Hovorka R

更新日期：2018-06-15 00:00:00

abstract：:This review article is focused on the sterilization techniques used for polymer-based implantable medical devices as well as the regulatory aspects governing sterile medical devices. Polymeric materials are increasingly used in implantable devices due to their biodegradable and biocompatible nature. Patients and medic...

journal_title：International journal of pharmaceutics

authors： Tipnis NP,Burgess DJ

更新日期：2018-06-15 00:00:00

abstract：:The aim of this study was to introduce a fast and reliable differential scanning calorimetry (DSC)-based method to determine the monomolecular loading capacity of drugs with good glass-forming ability in mesoporous silica (MS). The proposed method is based on a solvent-free melting/fusion of drug into the MS during a ...

journal_title：International journal of pharmaceutics

authors： Hempel NJ,Brede K,Olesen NE,Genina N,Knopp MM,Löbmann K

更新日期：2018-06-10 00:00:00

abstract：:The aim of the present study was to investigate the relationship between formulation/process variables versus the critical quality attributes (CQAs) of cyclosporine ophthalmic ointments and to explore the feasibility of using an in vitro approach to assess product sameness. A definitive screening design (DSD) was used...

journal_title：International journal of pharmaceutics

authors： Dong Y,Qu H,Pavurala N,Wang J,Sekar V,Martinez MN,Fahmy R,Ashraf M,Cruz CN,Xu X

更新日期：2018-06-10 00:00:00

abstract：:Piroxicam crystallises into two polytypes, α1 and α2, with crystal structures that contain identical molecular layers but differ in the way that these layers are stacked. In spite of having close structural similarity, the polytypes have significantly different powder tabletting behaviour: α2 forms only weak tablets a...

journal_title：International journal of pharmaceutics

authors： Upadhyay PP,Sun CC,Bond AD

更新日期：2018-05-30 00:00:00

abstract：:Particle detection and analysis techniques are essential in biopharmaceutical industries to evaluate the quality of various parenteral formulations regarding product safety, product quality and to meet the regulations set by the authority agencies. Several particle analysis systems are available on the market, but for...

journal_title：International journal of pharmaceutics

authors： Gross-Rother J,Herrmann N,Blech M,Pinnapireddy SR,Garidel P,Bakowsky U

更新日期：2018-05-30 00:00:00

abstract：:Flash nanoprecipitation (FNP) is a controlled antisolvent precipitation process that has proven effective for consistent production of drug nanoparticles with a defined mean particle size and narrow particle size distribution. However, physical instability of the generated nanoparticles remains a major challenge in th...

journal_title：International journal of pharmaceutics

authors： Wan KY,Wong KW,Chow AHL,Chow SF

更新日期：2018-05-05 00:00:00

abstract：:The self-organizing complexes with hyaluronic acid (HA) and polydopamine (PDA), an adhesion mediator via hydrogen bonding, were investigated for use as protein drug carriers. The complexes were prepared with HA of different molecular weights (20 kDa and 200 kDa) and various molar ratios of dopamine and lysozyme, a mod...

journal_title：International journal of pharmaceutics

authors： Lim DG,Prim RE,Kang E,Jeong SH

更新日期：2018-05-05 00:00:00

abstract：:Endothelial progenitor cells (EPCs) contribute to ischemic tissue repair by paracrine secretion up-regulated by hypoxia. In this study we use novel nanoparticles (NPs) as carriers for a controlled release of EPC secretome (CM) to improve their angiogenic properties. The in vivo effect in ischemic hindlimb rat model wa...

journal_title：International journal of pharmaceutics

authors： Felice F,Piras AM,Rocchiccioli S,Barsotti MC,Santoni T,Pucci A,Burchielli S,Chiellini F,Ucciferri N,Solaro R,Altomare A,Cecchettini A,Di Stefano R

更新日期：2018-05-05 00:00:00

abstract：:It is difficult to effectively eradicate C. albicans using traditional antifungal agents, mainly because the low permeability of the C. albicans cell wall creates strong drug resistance. The aim of this study was to investigate the synergistic fungicidal effect and the underlying mechanisms of low-frequency and low-in...

journal_title：International journal of pharmaceutics

authors： Yang M,Xie S,Adhikari VP,Dong Y,Du Y,Li D

更新日期：2018-05-05 00:00:00

abstract：:Currently, the compressed tablet and its oral administration is the most popular drug delivery modality in medicine. The accurate porosity and tensile strength characterization of a tablet design is vital for predicting its performance such as disintegration, dissolution, and drug-release efficiency upon administratio...

journal_title：International journal of pharmaceutics

authors： Xu X,Mack C,Cleland ZJ,Vallabh CKP,Dave VS,Cetinkaya C

更新日期：2018-05-05 00:00:00

abstract：:Hot-melt extrusion (HME) has gained increasing attention in the pharmaceutical industry; however, its potential in the preparation of solid self-emulsifying drug delivery systems (S-SMEDDS) is still unexplored. This study sought to prepare enteric S-SMEDDS by HME and evaluate the effects of the process and formulation...

journal_title：International journal of pharmaceutics

authors： Silva LAD,Almeida SL,Alonso ECP,Rocha PBR,Martins FT,Freitas LAP,Taveira SF,Cunha-Filho MSS,Marreto RN

更新日期：2018-04-25 00:00:00

abstract：:Poorly soluble drug molecules often have low bioavailability issues and absorption problems in the clinical setting. As the number of poorly soluble drugs increases from discovery, developing technologies to enhance their solubility, while also controlling their release is one of the many challenges facing the pharmac...

journal_title：International journal of pharmaceutics

authors： Otte A,Soh BK,Yoon G,Park K

更新日期：2018-03-25 00:00:00

abstract：:An innovative approach to improve drug delivery is the use of glycerol monooleate nanoparticles. Numerous studies describe their high versatility, low toxicity and ability to carry relatively high loads of conjugated compounds including scarcely soluble ones, providing sustained drug release and increasing drug diffus...

journal_title：International journal of pharmaceutics

authors： Valente F,Bysell H,Simoni E,Boge L,Eriksson M,Martini A,Astolfi L

更新日期：2018-03-25 00:00:00

abstract：:The purpose of this research was to study isomalt as a protein-stabilizing excipient with lactate dehydrogenase (LDH) during freeze-drying and subsequent storage and compare it to sucrose, a standard freeze-drying excipient. Four different diastereomer mixtures of isomalt were studied. The stability of the protein was...

journal_title：International journal of pharmaceutics

authors： Tuderman AK,Strachan CJ,Juppo AM

更新日期：2018-03-01 00:00:00

abstract：:The aim of the present work was the synthesis and study the kinetics and profiles of camptothecin (CPT) release form block co- and ter-polymer conjugates comprising polylactide (PLA) segments and CPT moieties, structurally diverse by degrees of branching, content of d-PLA units and poly(ethylene glycol) methyl ether m...

journal_title：International journal of pharmaceutics

authors： Plichta A,Kowalczyk S,Olędzka E,Sobczak M,Strawski M

更新日期：2018-03-01 00:00:00

abstract：:The most effective and safe contraceptive method, intrauterine devices (IUDs), is still underutilized due to the pain barrier during IUD insertion. Lidocaine, a well-known local anesthetic, can be used to relieve IUD insertion pain. This study aimed at formulation, in vitro, in vivo and clinical evaluation of a novel ...

journal_title：International journal of pharmaceutics

authors： Abd Ellah NH,Abouelmagd SA,Abbas AM,Shaaban OM,Hassanein KMA

更新日期：2018-03-01 00:00:00

abstract：:In this study, the inclusion complex formation between α-mangostin and water-soluble quaternized β-CD grafted-chitosan (QCD-g-CS) was investigated. Inclusion complex formation with encapsulation efficiency (%EE) of 5, 15 and 75% can be varied using high speed homogenizer. Tuning %EE plays a role on physicochemical and...

journal_title：International journal of pharmaceutics

authors： Phunpee S,Suktham K,Surassmo S,Jarussophon S,Rungnim C,Soottitantawat A,Puttipipatkhachorn S,Ruktanonchai UR

更新日期：2018-03-01 00:00:00

abstract：:A Therapeutic Nipple Shield (TNS) was previously developed to respond to the global need for new infant therapeutic delivery technologies. However, the release efficiency for the same Active Pharmaceutical Ingredient (API) from different therapeutic matrices within the TNS formulation has not yet been investigated. To...

journal_title：International journal of pharmaceutics

authors： Maier T,Scheuerle RL,Markl D,Bruggraber S,Zeitler A,Fruk L,Slater NKH

更新日期：2018-02-15 00:00:00

abstract：:Following vascular bypass interventions, autologous saphenous vein grafts are prone to fail due to intimal hyperplasia development. An atorvastatin (ATV)-eluting tubular mesh coated with poly(d,l-lactide-co-glycolisde) acid (PLGA) was designed for perivascular application, in order to prevent the development of this p...

journal_title：International journal of pharmaceutics

authors： Mylonaki I,Trosi O,Allémann E,Durand M,Jordan O,Delie F

更新日期：2018-02-15 00:00:00

abstract：:Combination strategy involving cyclodextrin (CD) complexation and liposomal system was investigated for Paclitaxel (PTX) to improve loading. Complexation was done using 2,6-di-O-methylbetacyclodextrin (DMβCD). Sterically stabilized double loaded PEGylated liposomes (DLPLs) containing PTX and PTX-DMβCD complex were pre...

journal_title：International journal of pharmaceutics

authors： Bhatt P,Lalani R,Vhora I,Patil S,Amrutiya J,Misra A,Mashru R

更新日期：2018-01-30 00:00:00

abstract：:In this study, a temperature and ROS-responsive drug delivery system ROSP@MSN based on mesoporous silica nanoparticles has been designed and synthesized by taking advantage of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate modified polymers (ROSP) as "nano-valve", which can respond selectively to cance...

journal_title：International journal of pharmaceutics

authors： Yu F,Wu H,Tang Y,Xu Y,Qian X,Zhu W

更新日期：2018-01-30 00:00:00

abstract：:Multiple sclerosis (MS) is the most common demyelinating disease. Despite the historical use of interferon-beta (IFN-β) for the treatment of patients with MS, concerns exist regarding the side effects of IFN-β. In this study, we designed a series of novel IFN-β fusion proteins containing galectin-9 (gal-9), which exer...

journal_title：International journal of pharmaceutics

authors： Hamana A,Takahashi Y,Tanioka A,Nishikawa M,Takakura Y

更新日期：2018-01-30 00:00:00

abstract：:N-(2-Hydroxypropyl) methacrylamide (HPMA) copolymer has been extensively studied as drug carrier for tumor therapy. Due to the Enhanced Permeability and Retention (EPR) effect, HPMA copolymer drug conjugates are able to be passively accumulated in the tumor site. Currently, efficient uptake of this polymeric system by...

journal_title：International journal of pharmaceutics

authors： Li L,Zhou M,Huang Y

更新日期：2018-01-30 00:00:00

abstract：:This study demonstrates the use of optical coherence tomography (OCT) to simultaneously characterize the roughness of the tablet core and coating of pharmaceutical tablets. OCT is a high resolution non-destructive and contactless imaging methodology to characterize structural properties of solid dosage forms. Besides ...

journal_title：International journal of pharmaceutics

authors： Markl D,Wahl P,Pichler H,Sacher S,Khinast JG

更新日期：2018-01-30 00:00:00

abstract：:Autophagy is a lysosomal degradation pathway that acts as a cytoprotective mechanism causing treatment resistance in various cancer cells. Recent studies showed that hydroxychloroquine can inhibit the latter step of autophagy and therefore enhance the anti-glioma efficiency of ZD6474, a tyrosine kinase inhibitor. Howe...

journal_title：International journal of pharmaceutics

authors： Wang X,Qiu Y,Yu Q,Li H,Chen X,Li M,Long Y,Liu Y,Lu L,Tang J,Zhang Z,He Q

更新日期：2018-01-30 00:00:00